Droxinostat, CAS 99873-43-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide

Purity: ≥98%

Formula Markup: C11H14ClNO3

Formula Weight: 243.7

CAS Number: 99873-43-5

Notes: Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively).{38617} It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM). Droxinostat increases histone H3 and H4 acetylation in PPC-1 prostate, OVCAR3 ovarian, U937 leukemia, HT-29 colon, and T47D breast cancer cells. It also inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of cellular FLICE-inhibitory protein (c-FLIP).{38618}

• SKU: CAY23869-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 23869-25
• Package Unit: 25 mg
• Quantity Unit: STK