DS-5272, CAS 1235575-97-9

Product Description: DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1].

Formula: C34H38Cl2F2N6O2S

References: [1]Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23(10):2360-7.

CAS Number: 1235575-97-9

Molecular Weight: 703.67

Research Area: Cancer

Target: Apoptosis;MDM-2/p53

• SKU: MEXHY-120667-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-120667-1
• Package Unit: 1 mg
• Quantity Unit: STK