DSM265, CAS 1282041-94-4

Product Description: DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2].

Applications: COVID-19-immunoregulation

Formula: C14H12F7N5S

References: [1]Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31./[2]Phillips MA, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015 Jul 15;7(296):296ra111.

CAS Number: 1282041-94-4

Molecular Weight: 415.33

Compound Purity: 99.76

Research Area: Infection

Solubility: DMSO : 50 mg/mL (ultrasonic)/Ethanol : 11.11 mg/mL (ultrasonic)

Target: Dihydroorotate Dehydrogenase;Parasite

• SKU: MEXHY-100184-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100184-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK