Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)-benzenesulfonamide
Purity: ≥98%
Formula Markup: C25H23F3N2O5S
Formula Weight: 520.521809
CAS Number: 1809427-19-7
Notes: A PP2A activator; increases the affinity of PP2A-B56α to a PP2A-A and PP2A-C dimer; does not induce phosphate release in a cell-free assay using B55α, B56α, or B56ε as the regulatory subunits; decreases Cer and hexosylceramide molar ratios and increases SM molar ratios in relation to PC in MCF-7 cells cultured with sphingosine; disrupts Golgi and endoplasmic reticulum integrity in HeLa cells; reduces tumor volume in an NCI H358 NSCLC mouse xenograft using cells that express wild-type PP2A-A but not those that express an PP2A-AR183W at 5 mg/kg; increases allograft survival in a murine heart transplantation model at 5 mg/kg
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