DTHIB, CAS 897326-30-6

Product Description: DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research[1].

Applications: Cancer-programmed cell death

Formula: C13H9ClFN3O3

References: [1]Bushu Dong, et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020 Dec 16;12(574):eabb5647.

CAS Number: 897326-30-6

Molecular Weight: 309.68

Compound Purity: 99.58

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: HSP

• SKU: MEXHY-138280-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138280-10
• Package Unit: 10 mg
• Quantity Unit: STK