DUPA(OtBu)-OH, CAS 1026987-94-9

Product Description: DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.

Applications: Cancer-programmed cell death

Formula: C23H40N2O9

References: [1]Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selectiveprostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103./[2]Lv Q, et al. Prostate-Specific Membrane Antigen Targeted Therapy of Prostate Cancer Using a DUPA-Paclitaxel Conjugate. Mol Pharm. 2018 May 7;15(5):1842-1852./[3]Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specificmembrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80.

CAS Number: 1026987-94-9

Molecular Weight: 488.57

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: PSMA

• SKU: MEXHY-103591-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103591-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK