Target: DUX4
Conjugate: RPE
Product Type: Monoclonal
Clone Number: P2B1
Immunogen: C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag
Swiss-Prot: F5GZ66
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~45kDa. No cross-reactivity with DUX4c.
Cellular Localization: Nucleus
Scientific Background: DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).
References: 1. Entrez Gene: “Dux4 Double Homeobox, 4”2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162.3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623.4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653.5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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