DYRK1A Inhibitor Compound 11, CAS 2814486-79-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N,N-dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine

Purity: ≥98%

Formula Markup: C12H12N6

Formula Weight: 240.26412

CAS Number: 2814486-79-6

Notes: DYRK1A inhibitor compound 11 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.4 nM).{68904} It is selective for DYRK1A over DYRK2, CDC-like kinase 1 (Clk1), Clk2, Clk3, cyclin-dependent kinase 2 (Cdk2), and glycogen synthase kinase 3β (GSK3β; IC50s = 19, 7.1, 9.4, 54, 100, and 94 nM, respectively) but does inhibit DYRK1B (IC50 = 2.7 nM). DYRK1A inhibitor compound 11 inhibits DYRK1A-induced increases in tau phosphorylation in a cell-based assay (IC50 = 590 nM).

• SKU: CAY41715-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41715-5
• Package Unit: 5 mg
• Quantity Unit: STK