(E/Z)-4-hydroxy Tamoxifen, CAS 68392-35-8

Formulation: A crystalline solid

Formal Name: 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

Purity: ≥98% (mixture of isomers)

Formula Markup: C26H29NO2

Formula Weight: 387,5

Shelf life (days): 1460

CAS Number: 68392-35-8

Notes: (E/Z)-4-hydroxy Tamoxifen is a mixture of (E)-4-hydroxy tamoxifen and (Z)-4-hydroxy tamoxifen.{28446} (Z)-4-hydroxy Tamoxifen is an active metabolite of the estrogen receptor antagonist tamoxifen (Item Nos. 13258 / 11629) and is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (Z)-4-hydroxy Tamoxifen (100 nM) inhibits 17β-estradiol-induced increases in the mRNA encoding progesterone receptor in MCF-7 breast cancer cells.{67256} (Z)-4-hydroxy Tamoxifen inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively).{28444}

• SKU: CAY17308-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17308-5
• Package Unit: 5 mg
• Quantity Unit: STK