E7046, CAS 1369489-71-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid

Purity: ≥98%

Formula Markup: C22H18F5N3O4

Formula Weight: 483.4

CAS Number: 1369489-71-3

Notes: E7046 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 13.5 nM).{64265} It inhibits PGE2-induced activation of pro-tumor type 2 macrophages and prevents PGE2-induced suppression of T cell proliferation in isolated human peripheral blood monocytes (PBMCs) when used at concentrations ranging from 0.1 to 3 µM. E7046 (5, 50, and 150 mg/kg) reduces tumor volume in Panc02 murine pancreatic and EMT6 murine breast cancer models.

• SKU: CAY19673-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19673-10
• Package Unit: 10 mg
• Quantity Unit: STK