EAI001, CAS 892772-75-7

Product Description: EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2].

Applications: Cancer-Kinase/protease

Formula: C19H15N3O2S

References: [1]Maity S, et, al. Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance. Pharmacol Rep. 2020 Aug;72(4):799-813./[2]Tinivella A, et, al. Investigating the selectivity of allosteric inhibitors for mutant t790m egfr over wild type using molecular dynamics and binding free energy calculations. 2018 Dec 4;3(12):16556-62.

CAS Number: 892772-75-7

Molecular Weight: 349.41

Compound Purity: 99.88

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: EGFR

• SKU: MEXHY-100214-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100214-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK