Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl] hydroxyamino]-5,5-dimethyl-2-oxo-1- imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Purity: ≥98%
Formula Markup: C27H25Cl2N7O7
Formula Weight: 630.4
CAS Number: 412960-54-4
Notes: Terminally misfolded proteins, recognized by chaperones on the endoplasmic reticulum (ER), are transported to depots for ubiquitination and proteasomal degradation by the ER-associated protein degradation (ERAD) pathway. Eeyarestatin 1 is an inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM.{15691} It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3.{27313,27314} Eeyarestatin 1, at 4 µM, interferes with both retrograde and anterograde trafficking of proteins, including certain toxins, and potentially, viruses.{27315}
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