EG00229 (trifluoroacetate), CAS 1210945-69-9

Product Description: EG00229 is a neuropilin 1 (NRP1) receptor antagonist. EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2[1].

Applications: Cancer-Kinase/protease

Formula: C19H20F3N7O7S3

References: [1]Jarvis A, et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26./[2]Grun D, et al. VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35(33):4379-87.

CAS Number: 1210945-69-9

Molecular Weight: 611.60

Compound Purity: 98.18

Research Area: Cancer

Solubility: DMSO : ≥ 41.4 mg/mL

Target: Complement System

• SKU: MEXHY-10799-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10799-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK