EGFR mutant-IN-2, CAS 2770009-06-6

Product Description: EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].

Applications: Cancer-Kinase/protease

Formula: C27H27F3N6O2S

References: [1]Dong H, et al. Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. J Med Chem. 2023 May 25;66(10):6849-6868.

CAS Number: 2770009-06-6

Molecular Weight: 556.60

Compound Purity: 97.0

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: EGFR

• SKU: MEXHY-155005-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155005-5
• Package Unit: 5 mg
• Quantity Unit: STK