Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: (aR,ßS)-rel-6-amino-ß-hexyl-a-methyl-9H-purine-9-ethanol, monohydrochloride
Purity: ≥95%
Formula Markup: C14H23N5O / HCl
Formula Weight: 313.8
CAS Number: 58337-38-5
Notes: EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).{20010,20014} Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).{20010} EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.{20013,20012,20011}
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