Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole
Purity: ≥98%
Formula Markup: C22H26N2O2S
Formula Weight: 382.5
CAS Number: 143322-58-1
Notes: Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D.{32188} It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1B antagonist SB216641 but not the 5-HT1D antagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively).{42283} Formulations containing eletriptan have been used in the treatment of migraine headache.
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