Product Description: Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Applications: Cancer-programmed cell death
Formula: C17H14N2
Citations: Front Cell Dev Biol. 2019 Sep 20;7:204./J Adv Res. 2023 Jun 6;S2090-1232(23)00148-0./J Cell Biol. 2023 Jan 2;222(1):e202202110.
References: [1]Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23./[2]Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105./[3]Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306.
CAS Number: 519-23-3
Molecular Weight: 246.31
Compound Purity: 99.56
Research Area: Cancer
Solubility: DMSO : 5.8 mg/mL (ultrasonic;warming)
Target: Topoisomerase
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