Eltanexor, CAS 1642300-52-4

Product Description: Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines[1].

Applications: Cancer-programmed cell death

Formula: C17H10F6N6O

References: [1]Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25.

CAS Number: 1642300-52-4

Molecular Weight: 428.29

Compound Purity: 99.84

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: CRM1

• SKU: MEXHY-100423-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100423-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK