EN6, CAS 1808714-73-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide

Purity: ≥95%

Formula Markup: C19H14F2N4O2

Formula Weight: 368.337026

CAS Number: 1808714-73-9

Notes: EN6 is an activator of autophagy.{50201} It inhibits mammalian target of rapamycin complex 1 (mTORC1) signaling by binding covalently to cysteine 277 of the ATP6V1A catalytic subunit of the lysosomal vacuolar ATPase (v-ATPase) and impairing v-ATPase coupling with Rag GTPases. It is selective for inhibition of mTORC1 over mTORC2 signaling. EN6 increases lysosome acidification and increases cellular clearance of TDP-43 protein aggregates, which are a pathological feature of several neurodegenerative diseases, in a v-ATPase-dependent manner in U2OS osteosarcoma cells. It also inhibits mTORC1 signaling and enhances autophagy in mouse skeletal muscle and heart when administered at a dose of 50 mg/kg.

• SKU: CAY28715-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28715-5
• Package Unit: 5 mg
• Quantity Unit: STK