Product Description: EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner[1].
Applications: Neuroscience-Neuromodulation
Formula: C19H14F2N4O2
References: [1]Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.
CAS Number: 1808714-73-9
Molecular Weight: 368.34
Compound Purity: 99.42
Research Area: Neurological Disease
Solubility: DMSO : 5 mg/mL (ultrasonic)/Ethanol : 1.11 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Autophagy
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