Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[1-(ethoxycarbonyl)-3-(phenyl-d5)propyl]-L-alanyl-L-proline, 2Z-butenedioate
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C20H23D5N2O5 / C4H4O4
Formula Weight: 497.6
CAS Number: 349554-02-5
Notes: Enalapril-d5 is intended for use as an internal standard for the quantification of enalapril (Item No. 16041) by GC- or LC-MS. Enalapril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 1.2 nM in porcine plasma).{43103} In vivo, enalapril (0.05-1 mg/kg, p.o.) inhibits pressor responses induced by angiotensin I (Item No. 24737) in rats and dogs in a dose-dependent manner. Enalapril reduces heart rate, systolic and diastolic blood pressures, and heart weight/body weight ratio in salt-sensitive and -resistant Dahl rats fed a high-salt or low-salt diet.{43104} Formulations containing enalapril have been used for the treatment of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.{25199}
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