Target Synonym: HHT;RP11 228B;Osler Rendu Weber syndrome;END;HHT1;ORW1;CD105;ENG;endoglin;AI528660;AI662476;CD 105;CD105 antigen;EGLN;FLJ41744;ORW;Osler Rendu Weber syndrome 1;RP11 228B15.2;S-endoglin;SN6;AI528660;AI662476;CD 105;CD105;CD105 antigen;EGLN;END;Endoglin;Eng;FLJ41744;HHT1;ORW;ORW1;Osler Rendu Weber syndrome 1;RP11 228B15.2;S-endoglin;SN6;ENG;END
Background: Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins (1-3). Endoglin and Betaglycan/T beta RIII are type III receptors for TGF beta superfamily ligands, sharing 71% aa identity in the transmembrane (TM) and cytoplasmic domains. Endoglin is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta, with lower amounts on hematopoietic, mesenchymal and neural crest stem cells, activated monocytes, and lymphoid and myeloid leukemic cells.
Immunogen: Recombinant Human Endoglin / CD105 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:200-1:2000;
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