Product Description: Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1].
Applications: COVID-19-immunoregulation
Formula: C11H13BrFN7O4S
References: [1]Liu X, et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010 Apr 29;115(17):3520-30./[2]Koblish HK, et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol Cancer Ther. 2010 Feb;9(2):489-98./[3]Fu R, et al. LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment. Br J Pharmacol. 2018 Jul;175(14):3034-3049.
CAS Number: 1204669-58-8
Molecular Weight: 438.23
Compound Purity: 99.66
Research Area: Inflammation/Immunology; Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Indoleamine 2,3-Dioxygenase (IDO)
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