Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone
Purity: ≥98%
Formula Markup: C36H35ClN4O4
Formula Weight: 623.14036
CAS Number: 1695533-44-8
Notes: Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.{35682,43340} It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).{43340} It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 (Item No. 17729) or deferoxamine (Item No. 14595).{35682} Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 µM).{35628} It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 µM.
English
Deutsch
