Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one
Purity: ≥98%
Formula Markup: C40H59NO11
Formula Weight: 729.9
CAS Number: 253128-41-5
Notes: Eribulin is an inhibitor of microtubule assembly and a derivative of the marine sponge macrolide halichondrin B.{66795} It inhibits the proliferation of U937 human lymphoma cells, as well as induces cell cycle arrest at the G2/M phase and, subsequently, apoptosis in the same cells when used at a concentration of 100 nM.{66796} Eribulin (1.5 mg/kg per week) reduces tumor growth in a patient-derived xenograft (PDX) mouse model of cutaneous squamous cell carcinoma.{66797} It also reduces tumor growth and increases survival in an intracerebral U87MG mouse xenograft model of glioblastoma when administered at a dose of 0.5 mg/kg three times per week.{66798} Formulations containing eribulin have been used in the treatment of metastatic breast cancer.
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