ERK5-IN-2, CAS 1888305-96-1

Product Description: ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis[1].

Applications: Cancer-Kinase/protease

Formula: C17H11BrFN3O2

References: [1]Myers SM, et al. Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. Eur J Med Chem. 2019 May 25;178:530-543.

CAS Number: 1888305-96-1

Molecular Weight: 388.19

Compound Purity: 98.96

Research Area: Cancer; Cardiovascular Disease

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: ERK

• SKU: MEXHY-128341-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-128341-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK