Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-(ethyl-1,1,2,2,2-d5)-3-methyl-2,5-pyrrolidinedione
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C7H6D5NO2
Formula Weight: 146.19808
CAS Number: 1989660-59-4
Notes: Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide (Item No. 23947) by GC- or LC-MS. Ethosuximide is an anticonvulsant.{36303,36304,36305,36306,36307} It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.{36303} Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.{36304} It also inhibits tonic hindlimb extension induced by pentylenetetrazole (PTZ; Item No. 18682) or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.{36305,36306} Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.{36307} Formulations containing ethosuximide have been used in the treatment of petit mal seizures.
English
Deutsch
