Shelf life (days): 1460.0
Formulation: An oil
Formal Name: 2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate-3,4,5,6-d4
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C18H14D4F3NO4
Formula Weight: 373.359309
CAS Number: 1329837-73-1
Notes: Etofenamate-d4 is intended for use as an internal standard for the quantification of etofenamate (Item No. 23674) by GC- or LC-MS. Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.
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