Description: Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
CAS Number: 202409-33-4
Formula: C18H15ClN2O2S
Molecular Weight: 358,84
References: Jayaraman R, et al. J Pharm Pharmacol. 2010, 62(5):610-4.