Ezetimibe, CAS 163222-33-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone

Purity: ≥98%

Formula Markup: C24H21F2NO3

Formula Weight: 409.4

CAS Number: 163222-33-1

Notes: Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1; Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes.{15337} It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day).{69254} Ezetimibe (346 nM) also reduces the levels of helper T cells and memory T cells isolated from the blood of heart transplant recipients.{69255} Formulations containing ezetimibe have been used in the treatment of primary hypercholesterolemia and mixed hyperlipidemia.

• SKU: CAY16331-250
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16331-250
• Package Unit: 250 mg
• Quantity Unit: STK