Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3R,4S)-1-(4-fluorophenyl-2,3,5,6-d4)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H17D4F2NO3
Formula Weight: 413.5
CAS Number: 1093659-89-2
Notes: Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe (Item No. 16331) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.{19679,15337} Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1.{19679,15337} Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.{19679,43023}
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