Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile, monohydrochloride
Purity: ≥98%
Formula Markup: C14H13N3 / HCl
Formula Weight: 259.73388
CAS Number: 102676-31-3
Notes: Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively).{38819,38820} It selectively inhibits estrogen over progesterone production induced by luteinizing hormone (LH) in hamster ovarian tissue as well as corticosterone and aldosterone production induced by adrenocorticotropic hormone (ACTH; Item No. 24257) in rat adrenal tissue (IC50s = 0.03, 160, 100, and 1 μM, respectively).{38819} It also decreases ovarian estrogen levels in rats when administered at a dose of 0.26 mg/kg.{38820} Fadrozole inhibits conversion of cholesterol to 27-hydroxycholesterol by the cytochrome P450 (CYP) isomer 27A1 (Ki = 4.6 μM).{38821} It inhibits growth of androstenedione-stimulated mammary D2 cells implanted into thoracic mammary fat pads of mice by 95% when administered at a dose of 0.5 mg per animal per day.{38822}
English
Deutsch
