Fazirsiran (sodium), CAS 2175009-09-1

Product Description: Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes[1]. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease.

Applications: Metabolism-protein/nucleotide metabolism

Formula: C493H610F11N163Na43O312P43S6

References: [1]Christine I Wooddell, et al. Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease. JCI Insight. 2020 Jun 18;5(12):e135348.

CAS Number: 2175009-09-1

Molecular Weight: 16532.90

Compound Purity: 93.86

Research Area: Metabolic Disease

Solubility: 10 mM in H2O

Target: Small Interfering RNA (siRNA)

• SKU: MEXHY-132604A-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-132604A-1
• Package Unit: 1 mg
• Quantity Unit: STK