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Encompassing Amino Acids: FcRn: 22-297, B2M: 1-119
Applications: Useful for the study of FcRn and Fc interactions and binding kinetics.
Description: Mouse FcRn also known as Neonatal Fc receptor is a heterodimer of FCGRT (Fc Fragment of IgG Receptor and Transporter) and B2M (beta 2 microglobulin), GenBank Accession numbers NM_010189 and NM_009735; a.a. 22-297 and a.a. 1-119 respectively. FCGRT has a C-terminal His-Avi-tag. This protein is enzymatically biotinylated using AviTagTM technology. These proteins are co-expressed in a HEK293 expression system. FcRn MW = 34 kDa, B2M MW = 14 kDa.
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Genbank: FcRn: NM_010189, B2M: NM_009735
Storage Stability: At least 6 months at -80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary use carrier protein (BSA 0.1 - 0.5%).
Tags: C-terminal His-Avi-Tag
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1.Roopenian, D., et al., Nature. 2007 Sep 7: 715-7252.Shields, R. et al., Biological Chemistry. 2000 Nov; 276:6591-6604.
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