FE65 blocking peptide

Species: Human

Specificity/Sensitivity: The peptide was used in the production of GTX89278.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservative.

Background: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Region Sequence: C-GSLKPKRLGAHTP

Full Name: amyloid beta precursor protein binding family B member 1

• SKU: GTX89278-PEP-100
• Manufacturer: GeneTex
• Manufacturer SKU: GTX89278-PEP-100
• Package Unit: 100 μg
• Quantity Unit: STK
• Human Gene ID: 322