Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole
Purity: ≥98%
Formula Markup: C12H13N3O3S
Formula Weight: 279.3
CAS Number: 59729-37-2
Notes: Fexinidazole is an antiparasitic agent.{62814} It is active against 15 strains of T. brucei, including T. b. rhodesiense, T. b. brucei, and T. b. gambiense (IC50s = 0.95-3.31 µM). Fexinidazole inhibits the growth of L. donovani at the promastigote and axenic amastigote stages (EC50s = 5.6 and 2.8 µM, respectively).{62816} Fexinidazole (50 to 30 mg/kg per day) reduces parasitic burden and increases survival in a mouse model of infection with benznidazole-susceptible, -partially resistant, or -resistant T. cruzi.{62817} Formulations containing fexinidazole have been used in the treatment of African sleeping sickness and Chagas disease.
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