FGTI-2734, CAS 1247018-19-4

Product Description: FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors[1].

Applications: Cancer-programmed cell death

Formula: C26H31FN6O2S

References: [1]Kazi A, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clin Cancer Res. 2019 Jun 21.

CAS Number: 1247018-19-4

Molecular Weight: 510.63

Compound Purity: 99.64

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Farnesyl Transferase

• SKU: MEXHY-128350-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-128350-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK