Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (5a,8a)-8-(1,1-dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol
Purity: ≥95%
Formula Markup: C15H28O3
Formula Weight: 256.38102
CAS Number: 869298-31-7
Notes: A ferroptosis inducer; an indirect GPX4 inhibitor and iron oxidizer; decreases GPX4 activity and protein levels in vitro; oxidizes iron in vitro; induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells at 10 µM; induces ferroptosis in an arachidonic acid lipoxygenase-independent manner; inhibits growth of and induces lethality in the NCI-60 panel of cancer cell lines (mean GI50 = 5.8 µM; mean LC50 = 46 µM); selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells at 15 and 20 µM; induces oxidative stress, including lipid peroxidation, in RS4;11 B-lymphoblastic leukemia cells at 6 µM
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