Firibastat, CAS 648927-86-0

Description: Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].

CAS Number: 648927-86-0

Formula: C8H20N2O6S4

Molecular Weight: 368,51

References: Ferdinand KC, et al. Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins. Circulation. 2019;140(2):138-146.

• SKU: TGMT28482-5mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T28482-5mg
• Package Unit: 5 mg
• Quantity Unit: STK