FITC Anti-Mouse CD206/MMR Antibody(C068C2)

Target Synonym: MMR;MR;MRC1;macrophage mannose receptor;mannose receptor

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Storage: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation Link 1: https://789.bio/ec/1yXLaT

Citation Link 2: C57BL/6 murine abdominal macrophages elicited by starch broth are stained with APC Anti-Mouse F4/80 Antibody and FITC Anti-Mouse CD206 Antibody (Left). Abdominal macrophages are stained with APC Anti-Mouse F4/80 Antibody and FITC Rat IgG2a, κ Isotype Control (Right).

Background: CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• SKU: ELSE-AB-F1135C-50
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: E-AB-F1135C-50
• Package Unit: 50 Tests
• Quantity Unit: PAK
• Reactivity: Mouse (Murine)
• Clonality: Monoclonal
• Application: Flow Cytometry
• Isotype: Rat IgG2a κ
• Human Gene ID: 17533
• Host: Rat
• Conjugate: Conjugated, FITC