Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
Purity: ≥95%
Formula Markup: C21H20ClNO5
Formula Weight: 401.83994
CAS Number: 146426-40-6
Notes: Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively).{23163} It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM.{23157} Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK293T cells (IC50 = In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model.{23163} It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.{23156}
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