Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime, 2Z-butenedioate
Purity: ≥95%
Formula Markup: C15H21F3N2O2 / C4H4O4
Formula Weight: 434.4
CAS Number: 61718-82-9
Notes: Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI).{63221} It selectively inhibits reuptake of serotonin over norepinephrine reuptake in rat hypothalamic synaptosomes (Kis = 6.2 and 1,100 nM, respectively). Fluvoxamine (10 mg/kg) reduces immobility time in the forced swim test in mice, an effect that can be blocked by the sigma-1 (σ1) receptor antagonist BD 1047 (Item No. 22928).{63222} It also reduces marble-burying behavior in the marble-burying test in mice when administered at a dose of 45 mg/kg, indicating anxiolytic- or reduced obsessive compulsive-like behaviors.{63223} Formulations containing fluvoxamine have been used in the treatment of obsessive compulsive disorder and social anxiety disorder.
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