FRAX1036, CAS 1432908-05-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-pyrido[2,3-d]pyrimidin-7(8H)-one

Purity: ≥98%

Formula Markup: C28H32ClN7O

Formula Weight: 518.1

CAS Number: 1432908-05-8

Notes: FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel (Item No. 11637).{32879} Disruption of PAK1 via FRAX1036 has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells.{32878}

• SKU: CAY20711-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20711-1
• Package Unit: 1 mg
• Quantity Unit: STK