Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,5-dichloro-N-(5-chloro-2-benzoxazolyl)-benzenesulfonamide
Purity: ≥98%
Formula Markup: C13H7Cl3N2O3S
Formula Weight: 377.6
CAS Number: 883973-99-7
Notes: Fructose-1,6-bisphosphatase-1 (FBPase-1) is an enzyme that catalyzes the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, which is one of the rate-limiting steps in gluconeogenesis. Excess hepatic FBPase-1 activity contributes to hyperglycemia in patients. Thus, the development of specific FBPase-1 inhibitors is of great clinical interest for the treatment of patients with type 2 diabetes. FBPase-1 inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that blocks human FBPase-1 enzymatic activity with an IC50 value of 3.4 µM (Ki = 1.1 µM) by competing at the AMP allosteric binding site.{30546,30547} It has been shown to block glucose production in rat hepatoma cells that are starved of nutrients with an IC50 value of 6.6 µM.{30546,30547}
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