Product Description: FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3].
Applications: Cancer-programmed cell death
Formula: C22H22O4
References: [1]EC Calvaresi. Small molecule inhibitors of lactate dehydrogenase a as an anticancer strategy. 2014./[2]Le A, et, al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42./[3]Mohammad GH, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel). 2019 Sep 16;11(9):1372.
CAS Number: 213971-34-7
Molecular Weight: 350.41
Compound Purity: 99.21
Research Area: Cancer
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: Apoptosis;Lactate Dehydrogenase;Reactive Oxygen Species
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