G-5555, CAS 1648863-90-4

Product Description: G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.

Applications: Cancer-Kinase/protease

Formula: C25H25ClN6O3

Citations: Acta Pharm Sin B. 2020 Apr;10(4):603-614./Elife. 2017 Mar 13;6:e22207. /Endocr Relat Cancer. 2019 Aug;26(8):699-712. /Exp Hematol. 2023 Sep 21;S0301-472X(23)01701-0./PLoS One. 2024 Jul 31;19(7):e0305121./Research Square Preprint. 2021 Apr./Endocr Relat Cancer. 2019 Aug;26(8):699-712.

References: [1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6./[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.

CAS Number: 1648863-90-4

Molecular Weight: 492.96

Compound Purity: 99.88

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)

Target: PAK

• SKU: MEXHY-19635-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-19635-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK