G140, CAS 2369751-07-3

Product Description: G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].

Applications: COVID-19-immunoregulation

Formula: C17H16Cl2N4O2

References: [1]Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261.

CAS Number: 2369751-07-3

Molecular Weight: 379.24

Compound Purity: 99.17

Research Area: Inflammation/Immunology

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: Cyclic GMP-AMP Synthase

• SKU: MEXHY-133916-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-133916-50
• Package Unit: 50 mg
• Quantity Unit: STK