G150, CAS 2369751-30-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-[9-(6-amino-3-pyridinyl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxy-ethanone

Purity: ≥95%

Formula Markup: C18H16Cl2N4O2

Formula Weight: 391.2508

CAS Number: 2369751-30-2

Notes: G150 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 10.2 nM for the human enzyme).{35986} It is selective for human cGAS over mouse cGAS (IC50 = 25,000 nM). G150 inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but not LPS-induced expresssion of TNF or poly(I:C)-induced rRNA degradation in the same cells when used at a concentration of 10 µM.

• SKU: CAY28318-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28318-1
• Package Unit: 1 mg
• Quantity Unit: STK