GAD1 Antibody - N-terminal region : FITC

Conjugation: FITC: Fluorescein Isothiocyanate

Description of Target: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GAD1

Molecular Weight: 67

Peptide Sequence: Synthetic peptide located within the following region: MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGF

Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.

Protein Name: Glutamate decarboxylase 1

Protein Size: 594

Purification: Affinity Purified

• SKU: AVIARP54353_P050FITC
• Manufacturer: Aviva Systems Biology
• Manufacturer SKU: ARP54353_P050-FITC
• Package Unit: 100μl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Rabbit, Dog (Canine), Guinea Pig, Cow (Bovine), Horse (Equine)
• Clonality: Polyclonal
• Application: Western Blotting
• Human Gene ID: 2571
• Host: Rabbit
• Conjugate: Conjugated, FITC