Product Type: Inhibitor
CAS No.: 1953-04-4
MolecularFormula: C17H22BrNO3
Molecular Weight: 368,3
Source: Synthetic
Purity: >97% (HPLC); NMR (Conforms)
Solubility: Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Appearance: White powder
PubChem CID: 121587
Scientific Background: Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors (1,2). It prevents β-amyloid-induced apoptosis in SH-SY5Y (3). Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice (4,5).
References: 1.M Racchi et al. Pharmacol. Res. 2004 50:4412.M Samochocki et al. J. Pharmacol. Exp. Ther. 2003 305:10243.E Arias et al. Neuropharmacology 2004 46:1034.K Rockwood et al. J. Neurol. Neurosurg. Psychiatry 2001 71:5895.S Chen et al. Curr. Neuropharmacol. 2007 5:127
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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